Viagra has no effect on liver patients

In the study, the scientists aimed at finding if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient (HVPG) in patients with cirrhosis. The study was conducted on ten patients with biopsy proven cirrhosis and an HVPG above 12 mmHg.
The scientists then measured the splanchnic blood flow and the HVPG during liver vein catheterisation before and 80 minutes after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick’s principle, with correction for non-steady state.

Though the scientists saw a decrease in arterial blood pressure 80 minutes after administration of the phosphodiesterase type-5 inhibitor sildenafil, they were unable to demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.

It was known that selective phosphodiesterase type-5 inhibitors, such as sildenafil, represent an important advance in management of erectile dysfunction. Scientists measured the HVPG and the estimation of splanchnic blood flow of the participants before and 80 minutes after oral administration of 50 mg of sildenafil.

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