Effects of sildenafil citrate on ejaculation latency, detumescence time, and refractory period: placebo-controlled, double-blind, crossover laboratory setting study

Objectives: To evaluate whether sildenafil citrate (SC) prolongs ejaculation latency and detumescence time and shortens the refractory period in a laboratory setting.

Methods: Two successive double-blind, placebo-controlled, crossover laboratory studies were performed with 30 different healthy volunteers in each study (total of 60). In the first study, the subject ingested placebo or SC. Real-time penile tumescence and rigidity monitoring and audiovisual sexual stimulation was performed. When the subject had his best erection, he applied vibratory stimulation until he ejaculated, and then audiovisual sexual stimulation was stopped. Monitoring was continued until he lost rigidity. The test was repeated with the second medication in 7 to 15 days. In the second study, another group of 30 volunteers were tested, as in the first study, and audiovisual sexual stimulation was continued for an additional hour after ejaculation.

Conclusions: In this laboratory setting, SC seemed to prolong the ejaculation latency time. The detumescence time was also longer, with better quality. However, we did not show that SC shortens the refractory period after ejaculation.

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