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ROYAL JELLY

Royal jelly is a milky secretion produced by worker honeybees. It typically contains about 60% to 70% water, 12% to 15% proteins, 10% to 16% sugar, 3% to 6% fats, and 2% to 3% vitamins, salts, and amino acids. Its composition varies depending on geography and climate.

This product gets its name from the fact that bees use it to nurture queen bees. Some people use royal jelly as medicine. Don’t confuse royal jelly with bee pollen, beeswax, bee venom, or propolis.

Royal jelly is used for symptoms of menopause. It is also used for diabetes, premenstrual syndrome (PMS), obesity, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

There is very little scientific information available about the effects of royal jelly in people. In animals, royal jelly seems to have some activity against tumors and the development of “hardening of the arteries.”

Uses & Effectiveness ?

Possibly Effective for

  • Symptoms of menopause. Most research shows that taking royal jelly for 8 weeks can improve symptoms of menopause. Also, applying royal jelly in the vagina may improve quality of life and sexual problems in some women. But applying estrogen inside the vagina seems to work better for reducing vaginal inflammation.

Possibly Ineffective for

  • Hay fever. Taking royal jelly by mouth for 3-6 months before and during pollen season does not seem to improve stuffy nose, sneezing, or eye discomfort in children with seasonal allergies.
  • Diabetes. Taking royal jelly does not seem to improve blood sugar levels in people with diabetes.
  • Physical performance in elderly adults. Taking royal jelly does not seem to improve hand grip strength, walking, or balance in elderly people living in a nursing home.

Insufficient Evidence for

  • Tiredness in people with cancer. Early research shows that taking a mixture of processed honey and royal jelly twice daily for 4 weeks improves feelings of tiredness in some people with cancer.
  • Kidney damage caused by cancer drugs. Cisplatin is a cancer drug that can cause kidney damage. Early research shows that royal jelly might prevent kidney damage in people receiving cisplatin.
  • Foot sores in people with diabetes. Some early research shows that applying royal jelly to foot sores does not improve healing. But other research shows that applying a specific ointment containing royal jelly and panthenol for up to 6 months may improve the healing of diabetic foot ulcers.
  • Dry eye. Early research shows that taking royal jelly does not improve dry eye symptoms.
  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Early research shows that taking royal jelly by mouth might lower cholesterol levels in people with high cholesterol.
  • Obesity. Some early research shows that taking royal jelly can decrease body weight by a small amount in some overweight people with diabetes. But other research shows that it does not improve body weight or appetite. If royal jelly does reduce body weight, it is likely to only be by a small amount.
  • Swelling (inflammation) and sores inside the mouth (oral mucositis). Swishing and swallowing royal jelly in addition to using regular rinses seems to improve the healing of these mouth sores better than using regular rinses alone.
  • Asthma.
  • Boosting immunity.
  • Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility).
  • Decline in memory and thinking skills in older people that is more than what is normal for their age. . .
  • Long-term kidney disease (chronic kidney disease or CKD).
  • Male-pattern baldness (androgenic alopecia).
  • Premenstrual syndrome (PMS).
  • Skin disorders. ulcers.
  • Swelling (inflammation) of the liver (hepatitis). ulcers.
  • Swelling (inflammation) of the pancreas (pancreatitis).

Side Effects

When taken by mouth: Royal jelly is POSSIBLY SAFE for most people when taken at appropriate doses. Doses up to 4.8 grams per day for up to 1 year have been used safely. In people with asthma or allergies, royal jelly might cause serious allergic reactions.

When applied to the skin: Royal jelly is POSSIBLY SAFE when applied to the skin appropriately. However, it has caused inflammation and allergic rash when applied to the scalp.

Special Precautions and Warnings

Children: Royal jelly is POSSIBLY SAFE when taken by mouth for up to 6 months in children 5-16 years of age.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if royal jelly is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Asthma or allergies: Don’t use royal jelly if you have asthma or allergies to bee products. It could cause some serious reactions, even death.

Inflamed skin (dermatitis): Royal jelly might make dermatitis worse.

Low blood pressure: Royal jelly might lower blood pressure. If your blood pressure is already low, taking royal jelly might make it drop too much.

Interactions ?

Moderate Interaction

Be cautious with this combination

Warfarin (Coumadin) interacts with ROYAL JELLY

Royal jelly might increase the effects of warfarin (Coumadin). Taking royal jelly with warfarin (Coumadin) might result in an increased chance of bruising or bleeding.

Dosing

The following doses have been studied in scientific research:

  • Symptoms of menopause: 1000 mg of royal jelly has been taken daily for 8 weeks. One or two capsules of a product containing royal jelly and flower pollen has been used for up to 12 weeks. Two capsules of a product containing royal jelly, evening primrose oil, damiana, and ginseng has been taken daily for 4 weeks.

Abd-Alhafiz AT, Abd-Almonem J. A simple treatment for asthenozoospermia-related subfertility: midcyclic pericoital vaginal micronized progesterone, bee honey and royal jelly. XVIII FIGO World Congress of Gynecology and Obstetrics. 2006;4(82)

Abdelatif, M., Yakoot, M., and Etmaan, M. Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study. J.Wound.Care 2008;17(3):108-110. View abstract.

Andersen, A. H., Mortensen, S., Agertoft, L., and Pedersen, S. [Double-blind randomized trial of the effect of Bidro on hay fever in children]. Ugeskr.Laeger 9-19-2005;167(38):3591-3594. View abstract.

Baldo, B. A. Allergies to wheat, yeast and royal jelly: a connection between ingestion and inhalation? Monogr Allergy 1996;32:84-91. View abstract.

Boukraa, Laïd. Additive Activity of Royal Jelly and Honey Against Pseudomonas aeruginosa. Alternative Medicine Review. 2008;13(4):330-333.

Calli C, Tugyan K Oncel S Pýnar E Demirtaþoglu F Calli A Yucel B Yýlmaz O Kiray A. Effectiveness of Royal Jelly on Tympanic Membrane Perforations: An Experimental Study. Journal of Otolaryngology — Head & Neck Surgery. 2008;37(2):179-184.

Chun SY, Feng TY Fu SY Kwong CC Jing GC. Royal jelly inhibited N-acetylation and metabolism of 2-aminofluorene in human liver tumor cells (J5). Toxicological & Environmental Chemistry. 2005;87:83-90.

Chupin SP, Sivokhov VL Bulnaeva GI. Use of Apilak (royal jelly) in sports medicine. Sports Training, Medicine & Rehabilitation. 1988;1(1):13-15.

El-Fiky S, Othman E Balabel E Abd-Elbaset S. The Protective Role of Royal Jelly Against Mutagenic Effect of driamycin and Gamma Radiation Separately and in Combination. Trends in Applied Sciences Research. 2008;3(4):303-318.

Erem, C., Deger, O., Ovali, E., and Barlak, Y. The effects of royal jelly on autoimmunity in Graves’ disease. Endocrine. 2006;30(2):175-183. View abstract.

Fontana, R., Mendes, M. A., de Souza, B. M., Konno, K., Cesar, L. M., Malaspina, O., and Palma, M. S. Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). Peptides 2004;25(6):919-928. View abstract.

Gasic S, Vucevic D Vasilijic S Antunovic M Chinou I Colic M. Evaluation of the Immunomodulatory Activities of Royal Jelly Components In Vitro. Immunopharmacology & Immunotoxicology. 2007;3-4:521-536.

Guo, H., Ekusa, A., Iwai, K., Yonekura, M., Takahata, Y., and Morimatsu, F. Royal jelly peptides inhibit lipid peroxidation in vitro and in vivo. J.Nutr.Sci.Vitaminol.(Tokyo) 2008;54(3):191-195. View abstract.

Guo, H., Saiga, A., Sato, M., Miyazawa, I., Shibata, M., Takahata, Y., and Morimatsu, F. Royal jelly supplementation improves lipoprotein metabolism in humans. J.Nutr.Sci.Vitaminol.(Tokyo) 2007;53(4):345-348. View abstract.

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Harada, S., Moriyama, T., and Tanaka, A. [Two cases of royal jelly allergy provoked the symptoms at the time of their first intake]. Arerugi 2011;60(6):708-713. View abstract.

Harwood, M., Harding, S., Beasley, R., and Frankish, P. D. Asthma following royal jelly. N.Z.Med.J. 8-23-1996;109(1028):325. View abstract.

Hattori, N., Nomoto, H., Fukumitsu, H., Mishima, S., and Furukawa, S. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed.Res. 2007;28(5):261-266. View abstract.

Inoue, S., Koya-Miyata, S., Ushio, S., Iwaki, K., Ikeda, M., and Kurimoto, M. Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp.Gerontol. 2003;38(9):965-969. View abstract.

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Mishima, S., Suzuki, K. M., Isohama, Y., Kuratsu, N., Araki, Y., Inoue, M., and Miyata, T. Royal jelly has estrogenic effects in vitro and in vivo. J.Ethnopharmacol. 10-3-2005;101(1-3):215-220. View abstract.

Mizutani, Y., Shibuya, Y., Takahashi, T., Tsunoda, T., Moriyama, T., and Seishima, M. Major royal jelly protein 3 as a possible allergen in royal jelly-induced anaphylaxis. J.Dermatol. 2011;38(11):1079-1081. View abstract.

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Munstedt, K., Henschel, M., Hauenschild, A., and von, Georgi R. Royal jelly increases high density lipoprotein levels but in older patients only. J.Altern.Complement Med. 2009;15(4):329-330. View abstract.

Nagai, T., Inoue, R., Suzuki, N., and Nagashima, T. Antioxidant properties of enzymatic hydrolysates from royal jelly. J.Med.Food 2006;9(3):363-367. View abstract.

Nakaya, M., Onda, H., Sasaki, K., Yukiyoshi, A., Tachibana, H., and Yamada, K. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci.Biotechnol.Biochem. 2007;71(1):253-255. View abstract.

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Okamoto, I., Taniguchi, Y., Kunikata, T., Kohno, K., Iwaki, K., Ikeda, M., and Kurimoto, M. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci. 9-5-2003;73(16):2029-2045. View abstract.

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Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. View abstract.

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