Viagra Gmp

How does Viagra Connect work?

Viagra Connect works by relaxing the blood vessels of the penis so more blood can flow into it. That means when a man becomes sexually aroused, he can get and maintain an erection.

What does Viagra Connect do?

When a man is sexually stimulated, impulses from the brain reach the cavernous nerve which releases nitric oxide (NO) at nerve endings in the penis. The NO diffuses across the endothelial cells into smooth muscle and stimulates the enzyme, guanylate cyclase, to convert GTP into cyclic GMP (cGMP).

Cyclic GMP starts a further cascade of biochemical reactions which results in smooth muscle relaxation and the cavernous bodies fill with blood and become rigid. Cyclic GMP is normally broken down by the enzyme PDE5 to GMP, which terminates the pathway and produces detumescence (Erection will subside).

Viagra Connect mode of action

Viagra Connect inhibits the action of this enzyme thus increasing cGMP levels and maintaining these levels for longer. Hence Viagra Connect helps a man attain and maintain an erection in response to sexual stimulation.

PDE5 inhibitor augments the normal physiological response to sexual stimulation
There is no effect in the absence of sexual stimulation

How long does it take Viagra Connect to work?

Because Viagra Connect is quickly absorbed, it only takes around 30–60 minutes to be effective, sexual stimulation is required for it to work. Viagra Connect will still be effective up to 4 hours after it is taken. After sex, the erection will go away as it would normally.

When taken with a high fat meal, the body takes longer to absorb Viagra Connect.

This means it will take a while longer to work, and this should be advised when recommending to customers.

PP-VUJ-GBR-0316 – December 2020

The blue diamond tablet shape and Viagra Connect®
are registered trademarks.

PP-VUJ-GBR-0432 – December 2020

Name of product: Viagra Connect® 50 mg film-coated tablets

Active ingredient: Sildenafil

Supply classification: Pharmacy supply (P)

Indications: For erectile dysfunction in adult men. Further information about this product, including essential supply information, adverse reactions, precautions, contraindications, and method of use can be found at: https://www.medicines.org.uk/emc/product/8725 or from Upjohn UK Limited, Walton Oaks, Surrey, KT20 7NS.

Viagra Connect® is available in packs of 2, 4 and 8 at RRP excluding VAT; 2 pack £9.16, 4 pack £16.66 and 8 pack £29.16, respectively.

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PP-VUJ-GBR-0450 – December 2020

Welcome to the VIAGRA connect ® UK site for healthcare professionals.

Within this site you can access information about VIAGRA connect ® 50 mg film-coated tablets (sildenafil). The information contained on this site is reserved exclusively for healthcare professionals resident in the UK.