Manforce 100mg Tab 4s Price : Rs. 211.00 Rs. 169.00

Uses of Manforce 100mg Tab 4s:

Sildenafil is used in the treatment of Erectile Dysfunction . Erectile dysfunction is the inability to achieve or maintain an erection long enough to perform sexual intercourse.

Side Effects of Manforce 100mg Tab 4s:

Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope, tachycardia, postural hypotension, MI, cerebral thrombosis, cardiac arrest, paraesthesia, tremor, depression, herpes simplex, skin ulcer, oesophagitis, abnormal LFT, rectal haemorrhage, hypoglycaemic reaction, arthritis, deafness, retinal vascular disease, photosensitivity, accidental fall.

Drug Interactions of Manforce 100mg Tab 4s:

Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Symptomatic hypotension when used with О±-blockers. Plasma concentrations are increased by ritonavir. Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil.

Contraindications of Manforce 100mg Tab 4s:

Hypersensitivity. Patients concurrently or intermittently using organic nitrates in any form.

Mechanism of Action of Manforce 100mg Tab 4s:

Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for cGMP degradation in the corpus cavernosum. Inhibition of PDE5 increases cGMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Absorption: Rapidly absorbed after oral admin. Bioavailability: about 40%. Distribution: Widely distributed. Plasma protein binding: 96%. Metabolism: Metabolised in the liver mainly by CYP3A4 and CYP2C9. Excretion: Excreted as metabolites mainly in the faeces.

Special Precautions for Manforce 100mg Tab 4s:

Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. sickle cell anaemia, myeloma, or leukaemia). Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders. May cause sudden loss or decrease in hearing.