How does Viagra work?
I know it gives you an erection but ­how does it do that? And why does Viagra only work when the man is sexually stimulated?
Responses (3)
Viagra (sildenafil) relaxes muscles and increases blood flow to particular areas of the body. Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men.
So how does it relax the muscles?
To understand how Viagra works we need to understand how an erection comes about.
Nitric Oxide (NO) is released with sexual stimulation from nerve endings and endothelial cells in the corpus cavernosum of the penis. An enzyme then converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). cGMP causes the smooth muscle of the penis to relax, which causes an inflow of blood which then leads to an erection. cGMP is then hydrolysed back to the inactive GMP by phosphodiesteras type 5 (PDE5).
Men who suffer from erectile dysfunction often produce too little amounts of NO. This means that the small amount of cGMP they produce is broken down at the same rate and therefore doesn't have the time to accumulate and cause a prolonged vasodilation effect.
Sildenafil (Viagra) works by inhibiting the enzyme PDE5. This means that cGMP is not hydrolysed as fast and this allows the smooth muscle to relax.
Sildenafil is a potent and highly selective inhibitor of PDE5.
These meds only work when sexually aroused because the brain really is the master sex organ. Only when visual, tactile, or other stimuli cause the "thought" of sex are hormones released from the brain to begin the cascade of events that result in an erection. Sometimes something blocks a step toward that end. Viagra removes the block so things can proceed normally. Until the process begins, there is nothing for Viagra to do.
When a man is sexually excited, viagra helps the penis fill with enough blood to cause an erection. it is taken about an hour before intercourse.
my hubby is usually good to go after 30 minutes of taking it . but 45 minutes to an hour really allows the med to give him and me the full "effect" .
Simple notes how viagra work: Viagra Inhibits an enzyme called phosphodiesterase type 5 (PDE-5), making muscle in the penis more likely to relax and allowing blood to flow in, causing an erection.
Further Information.
Search for questions.
Still looking for answers? Try searching for what you seek or ask your own question.
Similar Questions.
How does viagra work for people who suffer fom sexual dysfunctions caused from chronic prostatitis?
Posted 20 Nov 2010 • 1 answer.
What if viagra is taken and not nessarally needed for erectile dysfunction? What could happen to the.
Posted 26 Mar 2011 • 3 answers.
Will Viagra work for a Smoker too?
Posted 8 May 2011 • 6 answers.
I took 50mg viagra, then 4 hours later it didn't seem to work because I felt no effects?
Posted 23 Oct 2015 • 2 answers.
Erectile Dysfunction – I can only get it up with Viagra, and the broad has to be on top and work?
Posted 20 Apr 2017 • 1 answer.
You must sign in to view your friends.
Drugs.com Mobile Apps.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
Terms & Privacy.
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Sep 1st, 2017), Cerner Multum™ (updated Sep 4th, 2017), Wolters Kluwer™ (updated Sep 6th, 2017) and others. To view content sources and attributions, please refer to our editorial policy.
We comply with the HONcode standard for trustworthy health information – verify here.