Bosentan and Sildenafil: A Dual Amorphous Strategy for Enhanced Pharmacotherapy in Pulmonary Arterial Hypertension

Introduction: Two Old Drugs, One Persistent Problem Pulmonary arterial hypertension (PAH) remains one of the most devastating chronic cardiovascular disorders, characterized by elevated pulmonary artery pressure, progressive vascular remodeling, and eventual right heart failure. Despite the availability of several pharmacological…