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Viagra is one of the best-known treatments for erectile dysfunction (ED). ED is caused by insufficient blood flow to the penis, resulting in the inability to maintain an erection. Viagra can dramatically enhance the quality of an erection by increasing blood flow to the penis. Its effect lasts for 4-6 hours. Viagra is widely known to treat PAH (pulmonary arterial hypertension).

Other names for this medication:

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Active ingredient: Sildenafil Citrate.

Description

Viagra is an anti-impotence drug which enables men to achieve and sustain an erection.

The active ingredient of Viagra is Sildenafil Citrate (PDE-5 inhibitor). In response to sexual arousal, Sildenafil Citrate stimulates the release of nitric oxide (NO) in the corpus cavernosum. Nitric oxide activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This cyclic nucleotide relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection.

Along with the treatment of erectile disorders, Viagra effectively prolongs sexual performance, preventing premature ejaculation (PE).

Sildenafil Citrate is also used in the treatment of PAH (pulmonary arterial hypertension).

Viagra is also known as Aphrodil, Caverta, Kamagra, Suhagra, Edegra, Erasmo, Penegra, Revatio, Supra, Silagra, Zwagra.

Viagra does not protect you or your partner from sexually transmitted diseases (including HIV) or from pregnancy.

Take one Viagra pill orally with a full glass of water, 30-60 minutes before sex.

The dosage depends on the overall health of the patient. Do not take more than one pill per day.

Take Viagra on an empty stomach, as fatty meals, grapefruit juice and alcohol can interfere with the effectiveness of the medication.

If you take an overdose of Viagra, you should seek emergency medical attention or contact your healthcare provider immediately.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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Side effects

Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. The application of peripartum use of pulmonary artery catheter in pregnant patients with pulmonary hypertension. Bioequivalence of 2 Formulations of Sildenafil Oral Soluble Film 100 mg and Sildenafil Citrate (Viagra) 100 mg Oral Tablets in Healthy Male Volunteers. Molecular mechanisms that underlie the sexual stimulant actions of Avicennia marina (Forssk.) Vierh. and Crocus sativus L. Identification of phototransformation products of sildenafil (Viagra) and its N-demethylated human metabolite under simulated sunlight. Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway. Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy. Viagra. The effect of sildenafil on retinopathy of prematurity in very preterm infants. Erectile function of male rats in different age groups: an experimental study. The hidden impact of diabetes on male sexual dysfunction and fertility.

Contraindications

Do not take Viagra if you are allergic to any of ViagraвЂ™s components.

Do not take Viagra if you are also using organic nitrates, nitrate drugs for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate and isosorbide mononitrate), nitrates as amyl nitrate or nitrite (“poppers”).

Do not take Viagra if you take other medications to treat erectile dysfunction or pulmonary arterial hypertension, such as riociguat (Adempas).

Do not take Viagra if you are taking erythromycin, alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan).

Do not consume alcohol while using Viagra, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia).

Do not drive or operate machinery while taking the medication.

Contact you doctor or health care professional right away if your erection lasts longer than 4 hours or if it becomes painful.

Viagra does not protect you or your partner from sexually transmitted diseases or pregnancy.

Viagra can be dangerous for children and women.

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Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials. A novel approach incorporating sildenafil in the management of symptomatic neonates with Ebstein’s anomaly. The delivered promise of prenatal imaging and a challenge to the utility of sildenafil for severe lymphatic malformations. Development of acute lympboblastic leukemia in a patient with increased hematogones after toxic bone marrow damage. Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy. Sildenefil increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension. The ps in therapeutics. Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient’s satisfaction with treatment. Phosphodiesterase inhibitors, congestive heart failure, and sudden death: time for re-evaluation. cGMP-phosphodiesterase antagonists inhibit Ca2+-influx in Dictyostelium discoideum and bovine cyclic-nucleotide-gated-channel.

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Role of ATP-sensitive K+ channels in relaxation of penile resistance arteries. In vitro to in vivo extrapolation and physiologically based modeling of cytochrome P450 mediated metabolism in beagle dog gut wall and liver. 2009 update on phosphodiesterase type 5 inhibitor therapy part 2: updates on optimal utilization for sexual concerns and rare toxicities in this class. PDE-5 inhibitor donor intravenous preconditioning is superior to supplementation in standard preservation solution in experimental lung transplantation. Five years after the launch of Viagra in Korea: changes in perceptions of erectile dysfunction treatment by physicians, patients, and the patients’ spouses. Sarcoidosis-associated pulmonary hypertension: acute vasoresponsiveness to inhaled nitric oxide and the relation to long-term effect of sildenafil. Erectile disfunction after non nerve-sparing radical pelvic surgery. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Our clinical experience with the use of ++sildenafil citrate to treat erectile dysfunction. Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man.

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Long-term use of sildenafil. Results of double-blind placebo-controlled crossover study of sildenafil citrate (Viagra) in women suffering from obstructed voiding or retention associated with the primary disorder of sphincter relaxation (Fowler’s Syndrome). Sildenafil citrate for the management of antidepressant-associated erectile dysfunction. A comparative study of ethanolic extracts of Pedalium murex Linn. fruits and sildenafil citrate on sexual behaviors and serum testosterone level in male rats during and after treatment. Sex and the heart. Adherence to initial PDE-5 inhibitor treatment: randomized open-label study comparing tadalafil once a day, tadalafil on demand, and sildenafil on demand in patients with erectile dysfunction. Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies. Long-term efficacy of sildenafil and tachyphylaxis effect. Sildenafil modulates hemodynamics and pulmonary gas exchange. Efficacy and factors associated with successful outcome of sildenafil citrate use for erectile dysfunction after radical prostatectomy.

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Update in pulmonary hypertension associated with connective tissue diseases – a systematic literature review. Efficacy and limits of sildenafil citrate in patients with arterial erectile dysfunction: role of peripheral arterial disease and cardiovascular comorbidities. Four-year review of sildenafil citrate. Sildenafil decreased cardiac cell apoptosis in diabetic mice: reduction of oxidative stress as a possible mechanism. Sildenafil citrate therapy for pulmonary arterial hypertension. Is erectile dysfunction a marker for cardiovascular disease? Nightly vs on-demand sildenafil for penile rehabilitation after minimally invasive nerve-sparing radical prostatectomy: results of a randomized double-blind trial with placebo. Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats. Efficacy and safety of flibanserin “new female Viagra(В®)?”: Literature review. Four cases of erectile dysfunction in substance abusers treated with sildenafil.

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Effect of Sildenafil on Pressure-Volume Loop Measures of Ventricular Function in Fontan Patients. Safety and efficacy of sildenafil citrate in the treatment of Parkinson-emergent erectile dysfunction: a double-blind, placebo-controlled, randomized study. Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension. Chronic outpatient sildenafil therapy for pulmonary hypertension in a child after cardiac surgery. Peripheral and central activation of nitric oxide-cyclic GMP pathway by sildenafil. Effects of PDE type 5 inhibitors on left ventricular diastolic dysfunction in resistant hypertension. Subarachnoid and intracerebral hemorrhage after alcohol ingestion and illicit use of sildenafil. Potentiation of the NO-cGMP pathway and blood flow responses during dynamic exercise in healthy humans. The effects of sildenafil on smoke induced lung inflammation in rats. Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum.

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A study of clinical efficacy of sildenafil in patients with primary pulmonary hypertension. Novel use of sildenafil in the treatment of portopulmonary hypertension. Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5′-sulfonamide moiety of a phenyl ring. Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study. Is there a rationale for the chronic use of phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia? Phosphodiesterase isoenzymes in the human urethra: a molecular biology and functional study. Tadalafil and vardenafil vs sildenafil: a review of patient-preference studies. Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. A history of sexual medicine in the United kingdom. Sildenafil: study of a novel oral treatment for erectile dysfunction in diabetic men.

Anterior ischemic optic neuropathy associated with viagra. Treatment of dysautonomia associated with Parkinson’s disease. Treatment of erectile dysfunction after radical retropubic prostatectomy with PDE5 inhibitor. Invasive diagnosis and therapy–are they still reasonable in the age of sildenafil? One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease. A meta-regression analysis of treatment effect modifiers in trials with flexible-dose oral sildenafil for erectile dysfunction in broad-spectrum populations. Counterfeit Cialis and Viagra fingerprinting by ATR-FTIR spectroscopy with chemometry: can the same pharmaceutical powder mixture be used to falsify two medicines? Cavernous antioxidant effect of green tea, epigallocatechin-3-gallate with/without sildenafil citrate intake in aged diabetic rats. Giant neonatal thoraco-abdominal lymphatic malformations treated with sildenafil: a case report and review of the literature. Is there a rationale for the chronic use of phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia?

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Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products. Calcineurin/NFAT signaling pathway mediates endothelin-1-induced pulmonary artery smooth muscle cell proliferation by regulating phosphodiesterase-5. Investigation of sildenafil in the treatment of prostatitis-related sexual dysfunction. On-demand use of tramadol, sildenafil, paroxetine and local anaesthetics for the management of premature ejaculation: A randomised placebo-controlled clinical trial. Randomized, double-blind, placebo-controlled trial of sildenafil (Viagra) for erectile dysfunction after rectal excision for cancer and inflammatory bowel disease. Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension. Predictors of response to sildenafil citrate following radiation therapy for prostate cancer. Efficacy and factors associated with successful outcome of sildenafil citrate use for erectile dysfunction after radical prostatectomy. Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge. Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth.

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Juvenile diffuse systemic sclerosis/systemic lupus erythematosus overlap syndrome–a case report. Management of sexual dysfunction due to antipsychotic drug therapy. Does sildenafil enhance quality of nocturnal erections in healthy young men? A NPT-RigiScan study. Suspected acute exacerbation of idiopathic pulmonary fibrosis as an outcome measure in clinical trials. Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice. Influence of imatinib at a low dose and sildenafil on pulmonary hypertension in rats. Substance use, medications for sexual facilitation, and sexual risk behavior among traveling men who have sex with men. Clinical trials in patients with heart failure and preserved left ventricular ejection fraction. Enhanced cardioprotection against ischemia-reperfusion injury with combining sildenafil with low-dose atorvastatin. Oral sildenafil therapy for Chinese patients with pulmonary arterial hypertension: a multicenter study.

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The erection hardness score and its relationship to successful sexual intercourse. Mechanistic analysis of pH-dependent solubility and trans-membrane permeability of amphoteric compounds: application to sildenafil. Modeling and simulation of sexual activity daily diary data of patients with female sexual arousal disorder treated with sildenafil citrate (Viagra). Comparison of the therapeutic and side effects of tadalafil and sildenafil in children and adolescents with pulmonary arterial hypertension. Testosterone and chronic sildenafil/tadalafil anti-apoptotic role in aged diabetic rats. Sildenafil improves renal function in patients with pulmonary arterial hypertension. Treatment of pulmonary hypertension in children with chronic lung disease with newer oral therapies. Antiinflammatory sesquiterpenes from the root oil of Ferula hermonis. Characteristics of sildenafil erections in healthy young men. Identification system for Sildenafil in health foods.

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Contraceptive equity bills continue to gain. The immediate effect of sildenafil on right ventricular function in patients with heart failure measured by cardiac magnetic resonance: a randomized control trial. Preparation and characterization of bioadhesive systems containing propolis or sildenafil for dental pulp protection. Post-radical prostatectomy pharmacological penile rehabilitation: practice patterns among the international society for sexual medicine practitioners. Verification of the authenticity of drugs by means of NMR relaxometry-Viagra(В®) as an example. Sildenafil therapy is associated with improved hemodynamics in liver transplantation candidates with pulmonary arterial hypertension. Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease. The NO – K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. Effects of sildenafil citrate (viagra) on blood pressure in normotensive and hypertensive men. Pulmonary hypertension: inhaled nitric oxide, sildenafil and natriuretic peptides.

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Effects of sildenafil citrate, acetylcholine, and sodium nitroprusside on the relaxation of rabbit cavernosal tissue in vitro. A prospective study of the beneficial effects of dose optimization and customized instructions on patient satisfaction with sildenafil citrate (Viagra) for erectile dysfunction. Cognitive changes predict continued recovery of erectile functioning versus relapse after discontinuation of sildenafil treatment for male erectile dysfunction. Effects of sildenafil citrate (Viagra) on hemodynamic parameters during exercise testing and occurrence of ventricular arrhythmias in patients with erectile dysfunction and cardiovascular disease. Exercise-induced pulmonary artery hypertension in a patient with compensated cardiac disease: hemodynamic and functional response to sildenafil therapy. Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy. Horse metabolism and the photocatalytic process as a tool to identify metabolic products formed from dopant substances: the case of sildenafil. The impact of oral ED medication on female partners’ relationship satisfaction. Multi-level modeling to explain methamphetamine use among gay and bisexual men. Identification of phototransformation products of sildenafil (Viagra) and its N-demethylated human metabolite under simulated sunlight.

Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study. Negative impact of metabolic syndrome on the responsiveness to sildenafil in Japanese men. Erectile dysfunction medication use among men seeking substance abuse treatment. A comparison of different oral therapies versus no treatment for erectile dysfunction in 196 radical nerve-sparing radical prostatectomy patients. Structural elucidation of a new sildenafil analogue using high-resolution Orbitrap mass spectrometry. Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. A case of hypoglycemia due to illegitimate sexual enhancement medication. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs. Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. Intranasal microemulsion of sildenafil citrate: in vitro evaluation and in vivo pharmacokinetic study in rabbits.

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Sildenafil for psychotropic-induced sexual dysfunction in 31 women and 61 men. Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Relative efficacy of sildenafil compared to other treatment options for erectile dysfunction. Beneficial effect of oral sildenafil therapy on childhood pulmonary arterial hypertension: twelve-month clinical trial of a single-drug, open-label, pilot study. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil–review of the literature. Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy. Sildenafil in Cystic Hygroma. Efficacy of oral tadalafil, a new long-acting phosphodiesterase-5 inhibitor, for the short-term treatment of pulmonary arterial hypertension in a dog. Efficacy and safety of oral sildenafil in treatment of pediatric head and neck lymphatic malformations. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trial.

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Sildenafil improves six-minute walk distance in chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial. Recreational use of sildenafil by HIV-positive and -negative homosexual/bisexual males. Interaction of Viagra with the NO donors molsidomine and RE 2047 with regard to antithrombotic and blood pressure lowering activities. Sildenafil therapy in complex pulmonary atresia with pulmonary arterial hypertension. An open-label, multicenter, flexible dose study to evaluate the efficacy and safety of Viagra (sildenafil citrate) in Korean men with erectile dysfunction and arterial hypertension who are taking antihypertensive agents. Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension. Local therapies to heal the penis: fact or fiction? Evaluation of sildenafil pressurized metered dose inhalers as a vasodilator in umbilical blood vessels of chicken egg embryos. New directions in the treatment of antidepressant-induced sexual dysfunction. Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.

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