Introduction Organic erectile dysfunction (ED) has long been a clinical puzzle that stretches beyond the limits of oral pharmacotherapy. Although phosphodiesterase type 5 inhibitors (PDE5is) such as sildenafil and tadalafil revolutionized sexual medicine, their effectiveness is highly dependent on intact…
Month: September 2025
Introduction Few medical topics are as misunderstood—and as surrounded by silence—as female sexual dysfunction. Among its subcategories, Female Sexual Interest/Arousal Disorder (FSIAD) stands out, not because it is rare, but because it is so common and yet so undertreated. At…
Erectile dysfunction (ED) remains one of the most distressing complications for men with type 2 diabetes mellitus (T2DM). While pharmacological treatments such as phosphodiesterase-5 inhibitors (PDE5i) are widely prescribed, they do not always yield satisfactory results, nor are they appropriate…
Introduction Cardiovascular disease remains the leading cause of death in individuals with diabetes, and among its many manifestations, diabetic cardiomyopathy holds a particularly sinister reputation. Defined as structural and functional abnormalities of the myocardium in the absence of overt ischemia…
Introduction Medicine advances in curious cycles. For decades, the prevailing paradigm has been “bench to bedside”—a straight highway where discoveries in basic science are transported into the clinical realm. Yet, as physicians and patients alike know, highways are prone to…
Introduction The medical sciences have long struggled with one deceptively simple problem: how to know exactly what is present in a biological system, and in what quantity. Drugs, metabolites, and biochemical markers often share overlapping chemical signatures, making their detection…
Introduction The science of medicine has always been a dialogue between observation and measurement. For centuries, physicians relied on symptoms, physical signs, and intuition to guide therapy. But the past few decades have ushered in a profound transformation—one that leans…
Introduction Erectile dysfunction (ED) is a subject that simultaneously carries enormous clinical significance and a weight of cultural stigma. Defined as the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance, ED is not a trivial…
Introduction Ureteral stents are among the most frequently used devices in modern urology. They are indispensable in restoring urine flow, preserving renal function, and facilitating healing after ureteral surgery. Yet, despite their benefits, they have one notorious downside: stent-related discomfort…
Introduction Female sexual dysfunction (FSD) is a broad, multifaceted condition that challenges both clinicians and patients. It is not a singular disease but rather a constellation of disorders encompassing reduced desire, impaired arousal, orgasmic difficulties, and pain. Unlike male sexual…
Introduction Erectile dysfunction (ED) is more than a private inconvenience; it is a public health issue with significant psychological, relational, and medical consequences. Globally, it affects millions of men, and its prevalence is steadily rising due to aging populations, increasing…
Introduction Pulmonary hypertension (PH) remains one of the most formidable challenges in modern cardiology. Defined by abnormally elevated pulmonary arterial pressures, it is both a disease in itself and a complication of diverse cardiovascular and respiratory conditions. Patients with PH…
Introduction For as long as humanity has recorded its desires, aphrodisiacs have occupied an exalted—and sometimes suspicious—place in culture. From oysters consumed by Roman nobles to ginseng brewed in traditional Chinese medicine, the quest for enhanced sexual vitality transcends geography,…
Erectile dysfunction (ED) is often framed as a quality-of-life issue—awkward to discuss, easy to postpone, and, regrettably, frequently labeled “just stress.” That framing is dangerously incomplete. In many men, ED is an early clinical manifestation of systemic vascular disease, sometimes…